H2N2V1, Main, Exploration, bibRecord, 002B63

Effect of the interferon inducer, dextran phosphate, on influenza virus infection in mice.

Identifieur interne : 002B63 ( Main/Exploration ); précédent : 002B62; suivant : 002B64

Effect of the interferon inducer, dextran phosphate, on influenza virus infection in mice.

Auteurs : F. Suzuki ; N. Ishida ; M. Suzuki ; T. Sato ; S. Suzuki

Source :

Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) [ 0037-9727 ] ; 1975.

RBID : pubmed:1166077

Descripteurs français

KwdFr :
- Animaux, Dextrane (administration et posologie), Dextrane (analogues et dérivés), Dextrane (usage thérapeutique), Inducteurs de l'interféron (usage thérapeutique), Infections à Orthomyxoviridae (traitement médicamenteux), Injections péritoneales, Interférons (analyse), Orthomyxoviridae (pathogénicité), Oses phosphates (administration et posologie), Oses phosphates (usage thérapeutique), Poumon (anatomopathologie), Souris.
MESH :
- administration et posologie : Dextrane, Oses phosphates.
- analogues et dérivés : Dextrane.
- analyse : Interférons.
- anatomopathologie : Poumon.
- pathogénicité : Orthomyxoviridae.
- traitement médicamenteux : Infections à Orthomyxoviridae.
- usage thérapeutique : Dextrane, Inducteurs de l'interféron, Oses phosphates.
- Animaux, Injections péritoneales, Souris.

English descriptors

KwdEn :
- Animals, Dextrans (administration & dosage), Dextrans (analogs & derivatives), Dextrans (therapeutic use), Injections, Intraperitoneal, Interferon Inducers (therapeutic use), Interferons (analysis), Lung (pathology), Mice, Orthomyxoviridae (pathogenicity), Orthomyxoviridae Infections (drug therapy), Sugar Phosphates (administration & dosage), Sugar Phosphates (therapeutic use).
MESH :
- chemical , administration & dosage : Dextrans, Sugar Phosphates.
- chemical , analogs & derivatives : Dextrans.
- chemical , analysis : Interferons.
- chemical , therapeutic use : Dextrans, Interferon Inducers, Sugar Phosphates.
- drug therapy : Orthomyxoviridae Infections.
- pathogenicity : Orthomyxoviridae.
- pathology : Lung.
- Animals, Injections, Intraperitoneal, Mice.

Abstract

Intraperitoneal administration of dextran phosphate (MW 40,000) or DP 40, an interferon inducer, was shown to increase the survival rate of mice infected with 10 LD50 dose of influenza A2 virus (H2N2). In the treated mice, a 1-day delay was evident in the virus growth in lung, and production of HAI antibody, when compared to the nontreated or dextran-treated controls. More significant was the 2-day delay in the development of lung consolidation, which leads to 40% survival of the treated mice. Mediation of the protection by the interferon induced by DP 40 was indicated.

DOI: 10.3181/00379727-149-38960
PubMed: 1166077

Affiliations:

Le document en format XML

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<author><name sortKey="Suzuki, M" sort="Suzuki, M" uniqKey="Suzuki M" first="M" last="Suzuki">M. Suzuki</name>
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<term>Inducteurs de l'interféron (usage thérapeutique)</term>
<term>Infections à Orthomyxoviridae (traitement médicamenteux)</term>
<term>Injections péritoneales</term>
<term>Interférons (analyse)</term>
<term>Orthomyxoviridae (pathogénicité)</term>
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<term>Oses phosphates (usage thérapeutique)</term>
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<term>Mice</term>
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<front><div type="abstract" xml:lang="en">Intraperitoneal administration of dextran phosphate (MW 40,000) or DP 40, an interferon inducer, was shown to increase the survival rate of mice infected with 10 LD50 dose of influenza A2 virus (H2N2). In the treated mice, a 1-day delay was evident in the virus growth in lung, and production of HAI antibody, when compared to the nontreated or dextran-treated controls. More significant was the 2-day delay in the development of lung consolidation, which leads to 40% survival of the treated mice. Mediation of the protection by the interferon induced by DP 40 was indicated.</div>
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<name sortKey="Suzuki, F" sort="Suzuki, F" uniqKey="Suzuki F" first="F" last="Suzuki">F. Suzuki</name>
<name sortKey="Suzuki, M" sort="Suzuki, M" uniqKey="Suzuki M" first="M" last="Suzuki">M. Suzuki</name>
<name sortKey="Suzuki, S" sort="Suzuki, S" uniqKey="Suzuki S" first="S" last="Suzuki">S. Suzuki</name>
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Serveur d'exploration H2N2

Effect of the interferon inducer, dextran phosphate, on influenza virus infection in mice.

Effect of the interferon inducer, dextran phosphate, on influenza virus infection in mice.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

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